Anaphylaxis

If you or someone you know is experiencing an allergic reaction, please refer to your Allergy & Anaphylaxis Emergency Plan and call 911 immediately.

Anaphylaxis (an–a–fi–LAK–sis) is a serious allergic reaction that comes on quickly and has the potential to become life-threatening.

• Food, latex, insect stings and medicines can cause a severe allergic reaction⁽⁶⁾.
• Anaphylaxis includes a wide range of signs and symptoms that can occur alone, or in combination, after exposure to an allergen.
• Symptoms can develop rapidly after exposure to an allergen, often within minutes and usually within 30 minutes. However, it can take up to 2 hours for symptoms to occur after exposure to a food allergen. 
• Anaphylaxis requires immediate medical treatment, including an injection of epinephrine and a visit to the emergency room. Anaphylaxis can be fatal if not treated promptly. 
• Observation in a hospital for a period between 4 and 24 hours is recommended once the individual has returned to normal, due to concerns of biphasic anaphylaxis. 
• If you or someone you know is at risk of anaphylaxis, two epinephrine auto-injectable devices must be carried at all times. 

Each year in the U.S., it is estimated that severe reactions to food cause:

• 30,000 emergency room visits
• 2,000 hospitalizations
• 150 deaths⁽⁵⁾

Biphasic Anaphylaxis is the recurrence of symptoms within 1-72 hours after initial symptoms have resided, typically occurring within >8 hours after the initial reaction. Approximately 20% of anaphylactic reactions recur within 4-6 hours. ⁽⁷⁾

Biphasic reactions occur with no other exposure to an allergen and treated in the same manner as anaphylaxis. Biphasic incident reports vary, with some studies reporting occurrence in 25% of anaphylaxis cases, and may be more severe as the initial reaction.

Anaphylaxis: Signs and Symptoms Poster
Anaphylaxis FAACTs Poster
Allergy & Anaphylaxis Emergency Plan (AAP)
Anaphylaxis in the ED: A Reference for Physicians (ACAAI)
Epinephrine Auto-Injector Options

Anaphylaxis FAACT’s

• Food allergy is the leading cause of anaphylaxis.
• The sooner anaphylaxis is treated, the less severe it is likely to become.
• Delayed use of epinephrine has been associated with fatalities due to anaphylaxis. 
• Anaphylaxis can occur without hives, and some studies show that fatalities are more common when there is anaphylaxis without hives.
• The severity of a reaction cannot be accurately predicted by the degree of severity of past reactions.  An individual who previously had only “mild” reactions can later have dangerous and even life-threatening reactions. However, if an individual has a history of a severe reaction or anaphylaxis, then he/she is at high risk for having another severe reaction.
• In 70% of fatal or near fatal cases of food allergy reactions, there was either a delay in the administration of epinephrine, or epinephrine was not administered at all⁽⁸⁾.
• Asthma, chronic lung disease, and cardiovascular disease increases risk of death from anaphylaxis.
• In one study, 25% of anaphylactic reactions at school involved individuals whose allergy was unknown at the time of the reaction.
• Epinephrine CAN be used to treat the symptoms of an anaphylactic reaction and an asthma attack.  In fact, epinephrine was used to treat asthma attacks before other asthma medications were available.  Asthma medication, however, will NOT treat an anaphylactic reaction.  Speak to a board certified allergist for more information.
• All 50 states have laws allowing stock epinephrine. Only 11 states mandate schools to stock epinephrine, and the remainder states allow the option to stock this if they choose. There is a federal law that encourages states to pass laws allowing stock epinephrine.
• Visit FAACT's Education Resource Center for FREE and downloadable resources.

FAACT's FIST to THIGH "SIGN"

What would you do if you needed epinephrine...but you couldn't be heard?

Do you have a "SIGN"?

There might be a time when you are too far away for someone to hear you clearly or anaphylaxis is making it difficult to speak.

Here is a "SIGN" you can use...

 - Move in motion
 - FIST to THIGH
 - Wait a second
 - Repeat again
 - FIST to THIGH

Download this "SIGN" and share with others so they can quickly respond in an emergency.

And, please share this video to help FAACT spread the word about this potentially life-saving "SIGN"!

More About Anaphylaxis

The most common anaphylactic reactions are to foods, venom from insect bites or stings, medications, and latex.

Anyone with a previous history of anaphylactic reactions is at risk for having another severe reaction. Also at risk are those with a personal or family history of allergic conditions (asthma, eczema, or allergic rhinitis).  It is recommended to seek advice and treatment from a board-certified allergist, always carry two epinephrine auto-injectors (see graphic), and to obtain an Allergy & Anaphylaxis Emergency Plan.

Common associations with fatal food anaphylaxis are failure to administer epinephrine promptly, reactions involving peanuts and tree nuts, teenagers and young adults, patients with a history of food allergy and asthma, and individuals presenting respiratory symptoms.

Download FAACT's Poster for Epinephrine Auto-Injector Options.